| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-671-5p |
| Biological function: |
Promotes ESCC cell proliferation, migration, and invasion; associated with postoperative recurrence and metastasis. |
| Molecular mechanism: |
circMMP11 facilitates ESCC cellular behaviors by regulating miR-671-5p; luciferase reporter assay verified binding between circMMP11 and miR-671-5p. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; ROC Analysis; Bioinformatics Analysis; Cohort Study |
| Clinical significance: |
High circMMP11 expression is correlated with postoperative recurrence and metastasis, advanced TNM stage, positive lymph node metastasis, and has predictive value for postoperative recurrence/metastasis with AUC 0.838. |
| Description: |
circMMP11 is up-regulated in ESCC tissues and cells, especially in patients with postoperative recurrence/metastasis. It promotes ESCC cell proliferation, migration, and invasion, at least partly by regulating miR-671-5p, and may serve as a biomarker for predicting postoperative recurrence/metastasis. |
| Confidence score: |
0.8111 |