| Expression pattern: |
UP |
| Associated gene: |
programmed death-ligand 1 (PD-L1), PD-L1 |
| Associated microRNA: |
miR-1184 |
| Biological function: |
Promotes breast cancer cell growth, trastuzumab resistance, PD-L1 expression, and immune escape from CD8 T cell killing; knockdown reduces colony formation, sensitizes trastuzumab-resistant cells to trastuzumab, increases pro-inflammatory cytokines, decreases anti-inflammatory cytokines, and enhances CD8 T cell cytotoxicity. |
| Molecular mechanism: |
circ_0001598 acts as a miR-1184 sponge to regulate PD-L1 expression, thereby mediating trastuzumab resistance and immune escape in breast cancer cells. |
| Biological pathway or process: |
proliferation (promotes); drug resistance (promotes); immune regulation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Colony Formation Assay; MTT; ELISA; Western Blot; Survival Analysis; Cohort Study |
| Clinical significance: |
High circ_0001598 expression is associated with trastuzumab resistance and worse overall survival in breast cancer patients; circ_0001598 may be a molecular target to treat HER2-positive breast cancer patients. |
| Description: |
hsa_circ_0001598/circ_0001598 is up-regulated in HER2-positive breast cancer and further elevated in trastuzumab-resistant samples and cell lines. It promotes breast cancer cell proliferation, trastuzumab resistance, PD-L1 expression, and immune escape by sponging miR-1184 to regulate PD-L1. High circ_0001598 expression is associated with worse overall survival, suggesting potential clinical relevance as a therapeutic target in HER2-positive breast cancer. |
| Confidence score: |
0.7617 |