circRNA basic information
circBase ID: -
Name: hsa_circ_THBS1
Synonym: circTHBS1 / circRNA thrombospondin-1
Host Gene: THBS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

carcinoma tissues; para-carcinoma tissues; pulmonary puncture specimens; NSCLC tissue; normal tissue
Cell lines:

A549; SPC-A1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SOX4 / SRY-box transcription factor 4 (SOX4) gene
Associated microRNA: miR-129-5p
Biological function: circTHBS1 promotes NSCLC cell proliferation and inhibits apoptosis; its expression is higher in metastatic NSCLC than non-metastatic NSCLC.
Molecular mechanism: circTHBS1 acts as a ceRNA/miRNA sponge for miR-129-5p and regulates SOX4 expression.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot
Clinical significance:

circTHBS1 may be a potential risk factor and a promising diagnostic and prognostic biomarker of NSCLC.
Description:

circTHBS1 is up-regulated in NSCLC tissues and is higher in metastatic than non-metastatic NSCLC. The study indicates that circTHBS1 promotes NSCLC cell proliferation, suppresses apoptosis, and functions through a circTHBS1/miR-129-5p/SOX4 ceRNA mechanism, suggesting potential diagnostic, prognostic, and therapeutic relevance.
Confidence score:

0.6815
Other information
Title:

Circular RNA THBS1 promotes proliferation and apoptosis of non-small cell lung cancer cells by sponging miR-129-5p and regulating SOX4 expression.

Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology
Published: 2020
PubMed ID: 33099906
Study type:

combined biological and clinical study
Data availability: GSE101586; GEO, http://www.ncbi.nlm.nih.gov/geo
Code availability: -