circRNA basic information
circBase ID: -
Name: hsa_circ_RNF20
Synonym: circRNF20
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; normal tissues
Cell lines:

A549; H1299; H358; SPC-A1; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MAPK9
Associated microRNA: -
Biological function: circRNF20 promotes NSCLC cell proliferation; knockdown of circRNF20 decreases cell viability and colony formation.
Molecular mechanism: circRNF20 binds and activates MAPK9, thereby regulating NSCLC proliferation.
Biological pathway or process:

MAPK (promotes); proliferation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Luciferase Reporter Assay; Western Blot; Survival Analysis; Bioinformatics Analysis; Cohort Study
Clinical significance:

circRNF20 is correlated to T stage and poor prognosis in NSCLC patients and is an independent prognostic factor for NSCLC.
Description:

circRNF20 is up-regulated in NSCLC tissues and cell lines, correlates with advanced T stage, and high expression predicts poor prognosis. Functionally, circRNF20 promotes NSCLC cell proliferation, and its knockdown reduces cell viability and colony formation. Mechanistically, circRNF20 binds and activates MAPK9 to stimulate NSCLC proliferation.
Confidence score:

0.7365
Other information
Title:

CircRNF20 aggravates the progression of non-small-cell lung carcinoma by activating MAPK9.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 33090403
Study type:

combined biological and clinical study
Data availability: -
Code availability: -