| Expression pattern: |
UP |
| Associated gene: |
Sirt6, Ago2 |
| Associated microRNA: |
miR-125b-5p |
| Biological function: |
promotes keratinocyte cell viability and proliferation, promotes inflammation, and inhibits apoptosis in M5-stimulated HaCaT cells |
| Molecular mechanism: |
circVAPA functions as a competing endogenous RNA by sponging miR-125b-5p to up-regulate Sirt6 expression |
| Biological pathway or process: |
proliferation (promotes); inflammation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; ELISA; Western Blot |
| Clinical significance: |
potential therapeutic target for psoriasis; may provide a novel basis for diagnostic and therapeutic strategies |
| Description: |
circVAPA is up-regulated in psoriatic lesional skin and M5-stimulated HaCaT keratinocytes. It promotes keratinocyte proliferation and inflammatory cytokine production while suppressing apoptosis, acting through a ceRNA mechanism in which it sponges miR-125b-5p to increase Sirt6 expression. The study suggests circVAPA as a potential therapeutic target for psoriasis. |
| Confidence score: |
0.8119 |