circRNA basic information
circBase ID: hsa_circ_0047604
Name: hsa_circ_SMAD2
Synonym: circRNA-0047604
Host Gene: SMAD2
Genomic location(hg19): chr18:45371710-45377698:-
Genomic location(hg38): chr18:47845339-47851327:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; adjacent normal tissues
Cell lines:

MDA-MB-231; MCF-7; MCF-10A; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: DACH1
Associated microRNA: miR-548o
Biological function: Acts as a tumor suppressor by inhibiting breast cancer cell proliferation and migration.
Molecular mechanism: Functions as a miRNA sponge for miR-548o, thereby relieving repression of DACH1 and increasing DACH1 expression.
Biological pathway or process:

proliferation (inhibits); migration (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; Western Blot; CCK8; Colony Formation Assay; Wound Healing Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

This study reports that hsa_circ_0047604/circ_0047604 (derived from SMAD2) is down-regulated in breast cancer tissues. Functionally, it suppresses breast cancer cell proliferation and migration by sponging miR-548o, thereby increasing the tumor suppressor DACH1 expression (circ_0047604-miR-548o-DACH1 ceRNA axis).
Confidence score:

0.6521
Other information
Title:

The Function of circRNA-0047604 in Regulating the Tumor Suppressor Gene DACH1 in Breast Cancer.

Journal: BioMed research international
Published: 2022
PubMed ID: 35097124
Study type:

combined biological and clinical study
Data availability: All data included in this study are available upon request by contact with the corresponding author.
Code availability: -