| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1294 |
| Biological function: |
hsa_circ_0000936 promotes temozolomide resistance in glioma cells; knockdown of hsa_circ_0000936 increases TMZ sensitivity and increases apoptosis in TMZ-resistant glioma cell lines. |
| Molecular mechanism: |
hsa_circ_0000936 acts as a molecular sponge for miR-1294 to confer temozolomide resistance in glioma cells. |
| Biological pathway or process: |
apoptosis (inhibits); drug resistance (promotes); chemoresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry |
| Clinical significance: |
hsa_circ_0000936 is upregulated in glioma tissues and higher in tissues from TMZ-resistant patients; it may be a potential target for overcoming TMZ resistance in glioma. |
| Description: |
hsa_circ_0000936 is upregulated in glioma tissues, especially in tissues from patients resistant to temozolomide, and is also elevated in TMZ-resistant glioma cell lines. Functionally, hsa_circ_0000936 promotes TMZ resistance and suppresses apoptosis under TMZ treatment by sponging miR-1294; its knockdown sensitizes resistant glioma cells to TMZ. |
| Confidence score: |
0.6369 |