circRNA basic information
circBase ID: hsa_circ_0004030
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr3:41265511-41280845:+
Genomic location(hg38): chr3:41224020-41239354:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

tissues of gastric cancer, prostate cancer, and colorectal cancer
Cell lines:

AGS; HCT-116
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: hsa_circ_0004030 was upregulated in gastric cancer, prostate cancer, and colorectal cancer tissues, but its knockdown did not attenuate b-catenin activity in AGS and HCT-116 cells.
Molecular mechanism: No positive mechanism was reported; knockdown did not attenuate b-catenin activity.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0004030 was identified during screening of potential cis-acting circRNAs and was reported to be upregulated in gastric cancer, prostate cancer, and colorectal cancer tissues. Unlike circ-CTNNB1, its knockdown did not attenuate b-catenin activity in the tested cancer cells, and no positive functional mechanism or clinical prognostic role was further established.
Confidence score:

0.6368
Other information
Title:

Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.

Journal: Cancer research
Published: 2019
PubMed ID: 30563889
Study type:

combined biological and clinical study
Data availability: Supplementary Fig. S1A; Supplementary Fig. S1B; Supplementary Fig. S1C
Code availability: -