circRNA basic information
circBase ID: hsa_circ_0001625
Name: hsa_circ_BACH2
Synonym: circBACH2
Host Gene: BACH2
Genomic location(hg19): chr6:90836894-90837550:-
Genomic location(hg38): chr6:90127175-90127831:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; normal tissues
Cell lines:

MCF-7; MDA-MB-231
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HNRNPC
Associated microRNA: hsa-miR-944
Biological function: promotes BC cell proliferation
Molecular mechanism: Acts as a miRNA sponge for hsa-miR-944 to increase HNRNPC expression and activate MAPK/ERK phosphorylation.
Biological pathway or process:

MAPK (promotes); ERK (promotes); proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Western Blot; Transfection; CCK8; EdU Staining; Bioinformatics Analysis
Clinical significance:

-
Description:

circBACH2 (hsa_circ_0001625) is up-regulated in breast cancer and promotes breast cancer cell proliferation. It functions as a ceRNA by sponging hsa-miR-944 to increase HNRNPC expression and activate MAPK/ERK signaling.
Confidence score:

0.5008
Other information
Title:

Analysis and validation of m6A regulatory network: a novel circBACH2/has-miR-944/HNRNPC axis in breast cancer progression.

Journal: Journal of translational medicine
Published: 2021
PubMed ID: 34952600
Study type:

combined biological and clinical study
Data availability: TCGA (https://portal.gdc.cancer.gov/); GSE101123; GSE11121; Tang_2018 (http://kmplot.com/analysis/index.php?p=background)
Code availability: -