| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-502-5p |
| Biological function: |
promotes bladder cancer cell proliferation, invasion and tumorigenesis, and inhibits apoptosis |
| Molecular mechanism: |
Circ_0000735 acts as a ceRNA by sponging miR-502-5p in bladder cancer cells |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Circ_0000735 may be an effective molecular target for bladder cancer therapy |
| Description: |
Circ_0000735 is up-regulated in bladder cancer tissues and cell lines. It promotes bladder cancer cell proliferation, invasion and xenograft tumorigenesis while inhibiting apoptosis, at least partly by acting as a cytoplasmic ceRNA that sponges miR-502-5p. The study suggests Circ_0000735 may be a potential therapeutic target for bladder cancer. |
| Confidence score: |
0.7785 |