| Expression pattern: |
UP |
| Associated gene: |
MMP14 |
| Associated microRNA: |
hsa-miR-532-3p |
| Biological function: |
May be involved in carcinogenesis, prognosis and immune infiltration of LUAD via the hsa_circ_0072088/hsa-miR-532-3p/MMP14 axis. |
| Molecular mechanism: |
ceRNA mechanism: hsa_circ_0072088 sponges hsa-miR-532-3p to regulate MMP14. |
| Biological pathway or process: |
ceRNA regulation (other); immune regulation (other); prognosis (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Transfection; Luciferase Reporter Assay |
| Clinical significance: |
Might be involved in prognosis and immune infiltration of LUAD as a key regulatory axis (hsa_circ_0072088/hsa-miR-532-3p/MMP14). |
| Description: |
In LUAD, hsa_circ_0072088 is up-regulated and forms a ceRNA axis with hsa-miR-532-3p to modulate MMP14. This axis is proposed to contribute to carcinogenesis and relate to prognosis and immune infiltration, and was supported by qPCR and dual-luciferase assays plus perturbation experiments. |
| Confidence score: |
0.4851 |