circRNA basic information
circBase ID: -
Name: hsa_circ_LARP4
Synonym: circular RNA_LARP4
Host Gene: LARP4
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PCa tissues; para-cancer tissues; adjacent tissues
Cell lines:

LNCaP; DU145; 22Rv1; P69
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FOXO3A
Associated microRNA: -
Biological function: Circular RNA_LARP4 suppresses cell migration and invasion of prostate cancer cells and acts as a tumor suppressor in PCa.
Molecular mechanism: Circular RNA_LARP4 inhibits PCa migration and invasion by upregulating FOXO3A expression.
Biological pathway or process:

migration (inhibits); invasion (inhibits); metastasis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; Cohort Study; Survival Analysis
Clinical significance:

Low circular RNA_LARP4 expression was associated with poor prognosis of PCa patients.
Description:

Circular RNA_LARP4 is downregulated in prostate cancer tissues and cell lines, and low expression is associated with poorer overall survival. Functional experiments indicate that circular RNA_LARP4 overexpression suppresses DU145 cell migration and invasion, likely through upregulation of FOXO3A.
Confidence score:

0.6527
Other information
Title:

Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 32495863
Study type:

combined biological and clinical study
Data availability: -
Code availability: -