circRNA basic information
circBase ID: hsa_circ_0001829
Name: hsa_circ_SLC45A4
Synonym: -
Host Gene: SLC45A4
Genomic location(hg19): chr8:142264087-142264728:-
Genomic location(hg38): chr8:141253988-141254629:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent tissue samples; tissue microarray
Cell lines:

GES-1-T; GES-1-N; MKN-28; SGC-7901; MGC-803; BGC-823; 293-T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: SMAD2
Associated microRNA: miR-155-5p
Biological function: promotes GC cell proliferation, migration and invasion; promotes cell cycle progression; inhibits apoptosis; promotes tumor growth and metastasis/aggressiveness in vivo
Molecular mechanism: ceRNA mechanism: hsa_circ_0001829 sponges miR-155-5p to regulate SMAD2 expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
H
S
Validation methods:

RNA-seq; RT-qPCR; ISH (In Situ Hybridization); Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Bioinformatics Analysis; Clinical Sample Validation; Cohort Study
Clinical significance:

may offer novel biomarkers and therapeutic targets for GC
Description:

hsa_circ_0001829 is up-regulated in gastric cancer tissues and cell lines and promotes proliferation, migration, invasion, cell-cycle progression, and tumor growth/metastasis. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-155-5p to upregulate SMAD2, thereby driving GC progression.
Confidence score:

0.8595
Other information
Title:

Circular RNA hsa_circ_0001829 promotes gastric cancer progression through miR-155-5p/SMAD2 axis.

Journal: Journal of experimental & clinical cancer research : CR
Published: 2020
PubMed ID: 33308284
Study type:

combined biological and clinical study
Data availability: Supplementary material available at 10.1186/s13046-020-01790-w
Code availability: -