| Expression pattern: |
UP |
| Associated gene: |
MMP2, MAP2K6, PHLDA1, SLC12A2 |
| Associated microRNA: |
miR-604, miR-1248, miR-643, miR-520h, miR-1305, miR-1290 |
| Biological function: |
May contribute to brain metastasis in basal-like breast cancer via ceRNA interactions with miRNAs and metastasis-associated mRNAs (e.g., MMP2, MAP2K6). |
| Molecular mechanism: |
ceRNA network with miRNA sponging linking circ_0087558 to MMP2 and MAP2K6. |
| Biological pathway or process: |
ceRNA regulation (other); metastasis (promotes) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis |
| Clinical significance: |
Might be therapeutic targets or diagnostic biomarkers for basal-like breast cancer brain metastasis (based on bioinformatic analyses; needs experimental validation). |
| Description: |
circ_0087558 is reported as up-regulated in basal-like breast cancer brain metastasis tissues (vs primary) and is predicted to function in a ceRNA network by sponging miRNAs (e.g., miR-1248, miR-604, miR-643) to influence metastasis-related mRNAs such as MMP2 and MAP2K6. The evidence is based on RNA-seq and bioinformatic network analyses without experimental validation. |
| Confidence score: |
0.1768 |