circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1AS
Synonym: ciRS-7 / CDR1as
Host Gene: CDR1-AS
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005083
MONDO name: psoriasis
Disease details: psoriasis
Disease DO ID:
 8893
Disease MeSH ID:
 D011565
Disease NCIt ID:
 C3346
Disease ICD11 ID:
 63698555
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lesional skin; non-lesional skin; psoriatic skin biopsies; epidermis; dermis
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-7
Biological function: Unknown (no functional assays in psoriasis context); described as miRNA sponge in general.
Molecular mechanism: Assessed potential miRNA-binding-site loss on circRNAs; ciRS-7 is downregulated and visualized by CISH; no evidence that circRNAome changes explain miRNA expression differences.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
H
S
Validation methods:

RNA-seq; Bioinformatics Analysis; ISH (In Situ Hybridization); Clinical Sample Validation
Clinical significance:

-
Description:

ciRS-7 (CDR1as) is significantly down-regulated in lesional psoriatic skin, particularly in the epidermis. The study assessed circRNA-miRNA binding-site changes genome-wide and did not find evidence that circRNAome changes (including ciRS-7 reduction) explain miRNA expression differences between lesional and non-lesional skin.
Confidence score:

0.4032
Other information
Title:

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome.

Journal: BMC medical genomics
Published: 2019
PubMed ID: 31775754
Study type:

combined biological and clinical study
Data availability: Raw data available from the corresponding author on reasonable request; supplementary files (Additional file 7: Tables S1-S5; etc.).
Code availability: -