circRNA basic information
circBase ID: hsa_circ_0007006
Name: hsa_circ_DYM
Synonym: -
Host Gene: DYM
Genomic location(hg19): chr18:46783379-46808545:-
Genomic location(hg38): chr18:49257009-49282175:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HCT116; CRR-HCT116
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AKT3
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Predicted miRNA-mediated regulation affecting AKT3 (as one of the top three upregulated circRNAs).
Biological pathway or process:

ceRNA regulation (other); PI3K/AKT (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0007006 is upregulated in 5-FU-based chemoradiation-resistant CRC cells and its differential expression was validated by qRT-PCR. As one of the top three upregulated circRNAs, it is predicted to regulate AKT3 via miRNA-mediated interactions, potentially stabilizing AKT signaling in chemoradiation resistance.
Confidence score:

0.2465
Other information
Title:

Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.

Journal: BioMed research international
Published: 2017
PubMed ID: 28656150
Study type:

biological research; bioinformatics study
Data availability: -
Code availability: -