circRNA basic information
circBase ID: hsa_circ_0001874
Name: hsa_circ_BICD2
Synonym: circ_BICD2 / circ_0001874
Host Gene: BICD2
Genomic location(hg19): chr9:95500310-95500614:-
Genomic location(hg38): chr9:92738028-92738332:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma / OSCC
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tumor tissues; paired adjacent tissues; xenograft tumor tissues
Cell lines:

HSC-2; Tca8113; OSCC-15; SCC25; Ca9-22; SG; NOK; HEK-293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: HK2, AGO2
Associated microRNA: miR-107
Biological function: Promotes OSCC glycolysis, cell proliferation, migration, invasion, EMT-related changes, tumor growth and metastasis; circ_BICD2 knockdown exerts anti-tumorigenesis and anti-glycolysis effects.
Molecular mechanism: circ_BICD2 functions as a ceRNA that sponges miR-107 to upregulate HK2, thereby enhancing the HK2-mediated Warburg effect and promoting OSCC progression.
Biological pathway or process:

ceRNA regulation (promotes); glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Upregulated circ_BICD2 was closely related with tumor size, TNM stage and lymph node metastasis, and may serve as a potential therapeutic biomarker for OSCC clinical treatment.
Description:

circ_BICD2 is upregulated in OSCC tissues and cell lines and is associated with tumor size, TNM stage and lymph node metastasis. Functionally, circ_BICD2 promotes OSCC proliferation, migration, invasion, EMT-related phenotypes, tumor growth and aerobic glycolysis. Mechanistically, it acts as a ceRNA for miR-107 to enhance HK2 expression and the HK2-mediated Warburg effect.
Confidence score:

0.7548
Other information
Title:

circ_BICD2 acts as a ceRNA to promote tumor progression and Warburg effect in oral squamous cell carcinoma by sponging miR-107 to enhance HK2.

Journal: American journal of translational research
Published: 2020
PubMed ID: 32774714
Study type:

combined biological and clinical study
Data availability: -
Code availability: -