circRNA basic information
circBase ID: hsa_circ_0003221
Name: hsa_circ_PTK2
Synonym: circPTK2
Host Gene: PTK2
Genomic location(hg19): chr8:141856358-141900868:-
Genomic location(hg38): chr8:140846259-140890769:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer / BCa
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder carcinoma tissue; matched para-carcinoma tissue; metastatic lymph node tissue; blood samples; transplanted tumor tissues; metastatic axillary lymph nodes
Cell lines:

T24; 5637; BIU-87
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Promotes proliferation, migration, invasion, and metastasis of bladder cancer cells.
Molecular mechanism: Specific molecular mechanism was not investigated; the study functionally links high circPTK2 expression to proliferation, migration, invasion, and metastasis.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
S
Validation methods:

RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; BrdU; Transwell Assay; Wound Healing Assay; In Vivo Animal Model
Clinical significance:

circPTK2 levels in tissue and blood were correlated with poor differentiation, N2-N3 lymph node metastasis, and T(II-III-IV) stage; circPTK2 may be a potential biomarker and therapeutic target for bladder cancer diagnosis and therapy.
Description:

hsa_circ_0003221 (circPTK2) is up-regulated in bladder cancer tissues, patient blood, migrated cancer cells, and metastatic lymph nodes. Functional overexpression and knockdown experiments indicate that circPTK2 promotes bladder cancer cell proliferation, migration, invasion, and metastasis, and it may serve as a biomarker or therapeutic target, although the specific molecular mechanism was not defined.
Confidence score:

0.6278
Other information
Title:

Circular RNA hsa_circ_0003221 (circPTK2) promotes the proliferation and migration of bladder cancer cells.

Journal: Journal of cellular biochemistry
Published: 2018
PubMed ID: 29125888
Study type:

combined biological and clinical study
Data availability: -
Code availability: -