| Expression pattern: |
UP |
| Associated gene: |
E-cadherin, N-cadherin |
| Associated microRNA: |
- |
| Biological function: |
Promotes osteosarcoma cell invasion and migration; promotes EMT; associated with higher clinical stage and metastasis rate. |
| Molecular mechanism: |
High hsa_circ_0017247 promotes osteosarcoma invasion and migration through accelerating epithelial mesenchymal transformation, with decreased E-cadherin and increased N-cadherin expression. |
| Biological pathway or process: |
invasion (promotes); migration (promotes); metastasis (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Western Blot |
| Clinical significance: |
High expression of hsa_circ_0017247 was positively correlated with higher clinical stage and metastasis in osteosarcoma. |
| Description: |
hsa_circ_0017247 is up-regulated in osteosarcoma tissues and Saos-2 osteosarcoma cells. Its high expression is associated with advanced clinical stage and metastasis, and siRNA-mediated knockdown suppresses Saos-2 cell invasion and migration. The study suggests that hsa_circ_0017247 promotes osteosarcoma progression by accelerating EMT through regulation of E-cadherin and N-cadherin expression. |
| Confidence score: |
0.5214 |