| Expression pattern: |
UP |
| Associated gene: |
WEE1 |
| Associated microRNA: |
miR-124-3p |
| Biological function: |
Promotes proliferation, invasion, EMT, growth and metastasis of glioma cells; knockdown represses proliferation, invasion and EMT of T98G cells. |
| Molecular mechanism: |
circHIPK3 functions as a competing endogenous RNA that sponges miR-124-3p, thereby relieving miR-124-3p-mediated inhibition of WEE1 and up-regulating WEE1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); EMT (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
circHIPK3 may be a molecular target for clinical diagnosis and treatment of glioma. |
| Description: |
circHIPK3 is up-regulated in glioma tissues and glioma cell lines. It promotes glioma cell proliferation, invasion, EMT, growth and metastasis by sponging miR-124-3p and reducing miR-124-3p-mediated inhibition of WEE1. The study suggests circHIPK3 may serve as a molecular target for glioma diagnosis and treatment. |
| Confidence score: |
0.6479 |