circRNA basic information
circBase ID: -
Name: hsa_circ_RHOBTB3
Synonym: circular RNA RHOBTB3 / circRHOBTB3
Host Gene: RHOBTB3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008170
MONDO name: ovarian cancer
Disease details: ovarian cancer / OC
Disease DO ID:
 2394
Disease MeSH ID:
 D010051
Disease NCIt ID:
 C7431
Disease ICD11 ID:
 685124533
Disease OMIM ID:
 167000
Species: Human
Species details: Homo sapiens
Tissue specimen:

ovarian cancer tissue samples; paired adjacent normal tissues; tumor tissues; normal tissues
Cell lines:

HOSE; A2780; OV90
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: PI3K, p-PI3K, AKT, p-AKT, mTOR, p-mTOR, GLUT1, HK2, LDHA, N-cadherin, Vimentin, E-cadherin
Associated microRNA: -
Biological function: Suppresses ovarian cancer cell proliferation, migration, invasion, metastasis, EMT-related marker changes, glycolysis and tumor growth in vivo.
Molecular mechanism: circRHOBTB3 inhibits ovarian cancer progression by inactivating the PI3K/AKT signaling pathway, reducing p-PI3K, p-AKT and p-mTOR and suppressing glycolysis-related GLUT1, HK2 and LDHA expression.
Biological pathway or process:

PI3K/AKT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); glycolysis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot; In Vivo Animal Model
Clinical significance:

CircRHOBTB3 acted as a suppressor gene and might be a potential target in ovarian cancer.
Description:

circRHOBTB3 is down-regulated in ovarian cancer tissues and cells. It functions as a tumor suppressor by inhibiting proliferation, migration, invasion, metastasis, glycolysis and tumor growth, partly through inactivation of the PI3K/AKT signaling pathway.
Confidence score:

0.5802
Other information
Title:

Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway.

Journal: Panminerva medica
Published: 2024
PubMed ID: 32720791
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the present study are available from the corresponding author on reasonable request.
Code availability: -