| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-143-3p |
| Biological function: |
Promotes OS cell proliferation and glucose metabolism, inhibits apoptosis, and promotes xenograft tumour growth. |
| Molecular mechanism: |
circTUBA1C functions as a ceRNA sponge for miR-143-3p, inhibits miR-143-3p expression, and thereby promotes OS progression. |
| Biological pathway or process: |
proliferation (promotes); glycolysis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; In Vivo Animal Model |
| Clinical significance: |
circTUBA1C could potentially serve as a biomarker and therapeutic target for OS. |
| Description: |
circTUBA1C is upregulated in osteosarcoma tissues and cell lines. It promotes OS cell proliferation, glucose metabolism and xenograft tumour growth while suppressing apoptosis, mainly by sponging miR-143-3p. The study suggests circTUBA1C as a potential OS biomarker and therapeutic target. |
| Confidence score: |
0.6996 |