| Expression pattern: |
DN |
| Associated gene: |
EGFR, p38, cyclin D1, E-cadherin |
| Associated microRNA: |
- |
| Biological function: |
Overexpression of circ_4911 inhibited proliferation and migration of HUVECs, arrested cells at the G0/G1 stage, and promoted adhesion under an HCC microenvironment. |
| Molecular mechanism: |
circ_4911 overexpression suppressed activation of EGFR and p38 and reduced cyclin D1 expression, while increasing E-cadherin expression. |
| Biological pathway or process: |
EGFR (inhibits); MAPK (inhibits); proliferation (inhibits); migration (inhibits); cell cycle (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; Transfection; MTT; Transwell Assay; Cell Cycle Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
May provide new targets for HCC therapy; tissue validation and correlation with clinical characteristics remain to be analyzed. |
| Description: |
circ_4911 was one of the most significantly downregulated circRNAs in HUVECs exposed to an HCC microenvironment. Its overexpression inhibited endothelial proliferation and migration, induced G0/G1 arrest, promoted adhesion-associated E-cadherin expression, and suppressed EGFR/p38 activation, suggesting a regulatory role in HCC-associated endothelial cell dysfunction and angiogenesis-related processes. |
| Confidence score: |
0.5067 |