circRNA basic information
circBase ID: hsa_circ_0062558
Name: hsa_circ_MMP11
Synonym: circMMP11
Host Gene: MMP11
Genomic location(hg19): chr22:24125597-24126503:+
Genomic location(hg38): chr22:23783410-23784316:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary breast cancer tissue; adjacent normal breast tissue; paracancerous tissues
Cell lines:

HBL-100; MCF7; T47D; MDA-MB-453; MDA-MB-231; MDA-MB-468; Hs 578T; HEK-293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MMP11
Associated microRNA: miR-1204
Biological function: circMMP11 promotes breast cancer cell proliferation, migration and invasion; its knockdown suppresses these malignant phenotypes.
Molecular mechanism: circMMP11 functions as a ce-circRNA by sponging miR-1204, thereby regulating MMP11 expression in breast cancer.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay
Clinical significance:

circMMP11 is positively associated with lymph node metastasis and TNM stage and may serve as a potential therapeutic target in breast cancer.
Description:

circMMP11/hsa_circ_0062558 is upregulated in breast cancer tissues and cell lines and is associated with lymph node metastasis and TNM stage. It promotes breast cancer proliferation, migration and invasion by acting as a ce-circRNA sponge for miR-1204, thereby regulating MMP11 expression. The study suggests circMMP11 may be a potential therapeutic target in breast cancer.
Confidence score:

0.7858
Other information
Title:

CircMMP11 acts as a ce-circRNA in breast cancer progression by regulating miR-1204.

Journal: American journal of translational research
Published: 2020
PubMed ID: 32655792
Study type:

combined biological and clinical study
Data availability: TCGA
Code availability: -