circRNA basic information
circBase ID: mmu_circ_0014549
Name: mmu_circ_Phlpp2
Synonym: circPhlpp2 / mouse circPhlpp2
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Mouse
Species details: Mus musculus
Tissue specimen:

tumor tissues; blood
Cell lines:

MC38; CT26
In vivo animal model:

syngeneic model
circRNA-disease information
Expression pattern:
UN
Associated gene: IL36gamma
Associated microRNA: -
Biological function: promotes tumor growth in vivo, decreases NK-cell infiltration and NK-cell granzyme B/IFN-gamma production; its knockdown enhances anti-PD-1 efficacy in vivo
Molecular mechanism: circPhlpp2 promotes CRC progression partly via IL36gamma, affecting NK-cell infiltration and function
Biological pathway or process:

immune regulation (inhibits); proliferation (promotes)
Detected method:
Q
M
Validation methods:

Transfection; RT-qPCR; Western Blot; In Vivo Animal Model; Flow Cytometry（Non-apoptosis/cycle）; IHC (Immunohistochemistry); Survival Analysis; Microarray
Clinical significance:

-
Description:

In mouse CRC syngeneic models (MC38/CT26), circPhlpp2 promotes tumor growth by shaping the immune microenvironment, decreasing NK-cell infiltration and NK-cell cytotoxic cytokines (granzyme B, IFN-gamma). circPhlpp2 knockdown improves response to anti-PD-1 treatment in vivo, and IL36gamma acts as a functional downstream mediator.
Confidence score:

0.6474
Other information
Title:

Circular RNA circPHLPP2 promotes tumor growth and anti-PD-1 resistance through binding ILF3 to regulate IL36gamma transcription in colorectal cancer.

Journal: Molecular cancer
Published: 2024
PubMed ID: 39695693
Study type:

biological research
Data availability: 10.1186/s12943-024-02192-8
Code availability: -