| Expression pattern: |
UP |
| Associated gene: |
FABP5 |
| Associated microRNA: |
miR-620 |
| Biological function: |
Circ-ABCB10 acts as an oncogene in glioma; it promotes glioma cell proliferation, migration, invasion and cell cycle progression, and inhibits apoptosis. |
| Molecular mechanism: |
Circ-ABCB10 functions through a ceRNA-like mechanism by binding miR-620 and indirectly promoting/stabilizing FABP5 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
Circ-ABCB10 may be used as a potential therapeutic target for glioma. |
| Description: |
Circ-ABCB10 is up-regulated in glioma tissues and glioma cell lines. It promotes glioma cell proliferation, migration, invasion and cell cycle progression while suppressing apoptosis, at least partly through the miR-620/FABP5 regulatory axis. The study suggests circ-ABCB10 as a potential therapeutic target for glioma. |
| Confidence score: |
0.6835 |