| Expression pattern: |
UP |
| Associated gene: |
ZBED3, AGO2 |
| Associated microRNA: |
miR-1298-5p |
| Biological function: |
promotes GC cell viability and invasion and tumor growth, and inhibits apoptosis |
| Molecular mechanism: |
hsa_circ_0119412 sponges miR-1298-5p to upregulate ZBED3 expression (ceRNA mechanism) |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot |
| Clinical significance: |
hsa_circ_0119412 has the potential to be a molecular marker for GC screening. |
| Description: |
hsa_circ_0119412 is up-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes GC cell viability/invasion and tumor growth while inhibiting apoptosis by acting as a ceRNA sponge for miR-1298-5p to increase ZBED3 expression. |
| Confidence score: |
0.8119 |