| Expression pattern: |
UP |
| Associated gene: |
WNT1 |
| Associated microRNA: |
miR-185-5p |
| Biological function: |
promotes LUAD cell proliferation and survival; suppresses cell apoptosis |
| Molecular mechanism: |
circFOXP1 acts as a ceRNA sponge for miR-185-5p and upregulates WNT1 expression, thereby promoting LUAD progression |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; TUNEL; Western Blot |
| Clinical significance: |
may act as a prognostic biological marker and potential therapeutic target for LUAD |
| Description: |
circFOXP1 (hsa_circ_0008234) is up-regulated in LUAD tissues and cell lines. It promotes LUAD cell proliferation and suppresses apoptosis by acting as a miR-185-5p sponge and increasing WNT1 expression. The study suggests circFOXP1 may function as an oncogenic circRNA and potential therapeutic target in LUAD. |
| Confidence score: |
0.6815 |