circRNA basic information
circBase ID: hsa_circ_0067582
Name: hsa_circ_RASA2
Synonym: -
Host Gene: RASA2
Genomic location(hg19): chr3:141231004-141259451:+
Genomic location(hg38): chr3:141512162-141540609:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; paired adjacent non‐tumorous tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker and prognostic indicator for gastric cancer; lower expression associated with larger tumor diameter and longer overall survival.
Molecular mechanism: Predicted to act as a ceRNA/miRNA sponge with 18 potential miRNA binding sites, but not experimentally validated in this study.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

divergent primers PCR; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Survival Analysis
Clinical significance:

AUC=0.6937 for distinguishing GC tissues from adjacent normal tissues; low hsa_circ_0067582 group had longer overall survival.
Description:

hsa_circ_0067582 is significantly down-regulated in gastric cancer tissues versus adjacent normal tissues and shows moderate diagnostic performance by ROC analysis. Lower expression is associated with longer overall survival, suggesting potential prognostic value. Mechanistically, the study only provides bioinformatic prediction that it may function as a miRNA sponge (ceRNA), without experimental validation of specific miRNAs or downstream targets.
Confidence score:

0.6355
Other information
Title:

Reduced expression of circRNA hsa_circ_0067582 in human gastric cancer and its potential diagnostic values.

Journal: Journal of clinical laboratory analysis
Published: 2020
PubMed ID: 31721300
Study type:

combined biological and clinical study
Data availability: GSE89143
Code availability: -