circRNA basic information
circBase ID: hsa_circ_0000006
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:1601102-1666274:-
Genomic location(hg38): chr1:1669663-1734835:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OS tissues; para-carcinoma tissue samples / adjacent tissues / neighboring tissues
Cell lines:

hFOB1.19; U2OS; Saos-2; HOS; MG-63
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: LRIG1
Associated microRNA: miR-361-3p
Biological function: Promotes osteosarcoma cell proliferation, migration, invasion and EMT; knockdown promotes OS progression in vitro.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-361-3p to regulate LRIG1 expression (hsa_circ_0000006/miR-361-3p/LRIG1 axis).
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot
Clinical significance:

Proposed as a biomarker and therapeutic target for osteosarcoma.
Description:

hsa_circ_0000006 is down-regulated in osteosarcoma tissues and cell lines. Functionally, it promotes OS malignant phenotypes (proliferation, migration, invasion and EMT) by sponging miR-361-3p and thereby regulating LRIG1 in a ceRNA axis.
Confidence score:

0.7283
Other information
Title:

hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma.

Journal: Annals of translational medicine
Published: 2021
PubMed ID: 34532379
Study type:

combined biological and clinical study
Data availability: GSE140256; GSE65071; GSE87624
Code availability: -