circRNA basic information
circBase ID: hsa_circ_0009117
Name: hsa_circ_RERE
Synonym: circ_0009117
Host Gene: RERE
Genomic location(hg19): chr1:8555122-8674745:-
Genomic location(hg38): chr1:8495062-8614686:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

cerebrospinal fluid / CSF; plasma; tumor tissue
Cell lines:

A549; HCC827
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: Wnt-2, Wnt-3, Wnt-5a, FZD, DVL3, PORCN, TCF
Associated microRNA: -
Biological function: promotes cell proliferation; promotes invasion
Molecular mechanism: Predicted ceRNA network involvement with WNT signaling-related targets; functional inference from knockdown in vitro.
Biological pathway or process:

Wnt/beta-catenin (other); proliferation (promotes); invasion (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Transfection; MTT; Transwell Assay; Colony Formation Assay; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Included in 60 CSF-circRNAs that were identified and associated with shorten overall survival.
Description:

hsa_circ_0009117 (RERE-derived) was selected as a WNT-associated CSF circRNA candidate and showed pro-proliferative/invasive effects in A549 upon knockdown, but it was not detected in CSF in an independent RT-PCR validation cohort, lowering overall evidence for its clinical detectability.
Confidence score:

0.6046
Other information
Title:

Clinical utility of cerebrospinal fluid-derived circular RNAs in lung adenocarcinoma patients with brain metastases.

Journal: Journal of translational medicine
Published: 2022
PubMed ID: 35123506
Study type:

combined biological and clinical study
Data availability: The data used and/or analyzed during the current study are available from the corresponding author on reasonable request.; 10.1186/s12967-022-03274-1
Code availability: -