| Expression pattern: |
UP |
| Associated gene: |
ATP8B4 |
| Associated microRNA: |
Hsa-mir-605-3p, Hsa-mir-101-5p, Hsa-mir-31-5p, Hsa-mir-215-3p, Hsa-mir-766-5p |
| Biological function: |
Potential diagnostic biomarker; associated with hematologic disorder-related indices in RA |
| Molecular mechanism: |
miRNA target prediction suggests potential sponge mechanism (not experimentally validated) |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Peripheral blood hsa_circ_0035197 can distinguish new-onset RA patients from HC, AS patients, SLE patients, and UA patients; combination with hsa_circ_0002715 provides best diagnostic accuracy (AUC 0.758). |
| Description: |
hsa_circ_0035197 is up-regulated in peripheral blood of new-onset RA patients and has diagnostic value versus healthy controls and other disease groups including UA. It is implicated as a biomarker potentially associated with hematological involvement, and predicted miRNA targets suggest a possible miRNA-sponge role. |
| Confidence score: |
0.459 |