| Expression pattern: |
UP |
| Associated gene: |
PDK1, AGO2 |
| Associated microRNA: |
miR-516b |
| Biological function: |
Promotes growth, proliferation, colony formation, migration, metastasis ability, glucose uptake and lactate production in papillary thyroid cancer cells. |
| Molecular mechanism: |
circRAD18 acts as a cytoplasmic sponge for miR-516b and promotes PDK1 expression, thereby reprogramming glucose metabolism in papillary thyroid cancer. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential novel therapeutic target for papillary thyroid cancer metabolic reprogramming progression. |
| Description: |
circRAD18 is upregulated in papillary thyroid cancer tissues and cell lines. It promotes papillary thyroid cancer cell growth, migration/metastatic behavior, and glucose metabolism reprogramming by sponging miR-516b and enhancing PDK1 expression, suggesting potential therapeutic relevance. |
| Confidence score: |
0.8119 |