| Expression pattern: |
UP |
| Associated gene: |
MSI1 |
| Associated microRNA: |
miR-125-5p |
| Biological function: |
promotes chemoresistance to 5-fluorouracil and oxaliplatin; promotes migration and invasion; inhibits apoptosis |
| Molecular mechanism: |
ceRNA mechanism: circ_0032833 sponges miR-125-5p to regulate MSI1 expression |
| Biological pathway or process: |
drug resistance (inhibits); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
associated with FOLFOX therapy response (higher in Nonresponders) and proposed as a diagnostic target for resistance generation |
| Description: |
circ_0032833 is up-regulated in FOLFOX-resistant colorectal cancer and promotes resistance to 5-fluorouracil and oxaliplatin. Mechanistically, it sponges miR-125-5p to increase MSI1 expression, thereby enhancing malignant behaviors and decreasing chemosensitivity; its knockdown sensitizes tumors in vitro and in a cell line-derived xenograft model. |
| Confidence score: |
0.705 |