| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Plasma hsa_circ_0139897 serves as part of a diagnostic circRNA panel for HBV-related HCC, Small-HCC, AFP-negative HCC and AFP-negative Small-HCC; it is secreted by HCC cells into plasma and is higher in HCC plasma. |
| Molecular mechanism: |
No molecular mechanism was functionally defined; the study supports that HCC cells secrete this circRNA into plasma and that its plasma expression correlates with HCC tissue expression. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Microarray; Clinical Sample Validation; In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0139897 was included in a plasma CircPanel that performed better than AFP in diagnosing HCC and Small-HCC and also identified AFP-negative HCC and AFP-negative Small-HCC effectively. |
| Description: |
hsa_circ_0139897 is up-regulated in plasma from HBV-related HCC patients, positively correlated with expression in HCC tissues, and decreases after hepatectomy, although HCC versus ANL tissue expression was not significantly different. It is secreted by HCC cells into plasma and was incorporated into a three-circRNA diagnostic panel that outperformed AFP for detecting HCC and related clinical subgroups. |
| Confidence score: |
0.7352 |