| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-217 |
| Biological function: |
Promotes proliferation and migration of lung cancer cells and induces malignant progression of lung cancer. |
| Molecular mechanism: |
circABCB10 binds to microRNA-217 and negatively regulates its expression, suggesting a ceRNA mechanism by which circABCB10 promotes lung cancer progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circABCB10 expression is related to poor prognosis of lung cancer patients and may be a new target for diagnosis and treatment. |
| Description: |
circABCB10 is up-regulated in lung cancer tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circABCB10 promotes lung cancer cell proliferation and migration. Mechanistically, circABCB10 binds to and down-regulates microRNA-217, forming a circABCB10/microRNA-217 regulatory axis that contributes to lung cancer progression. |
| Confidence score: |
0.7126 |