circRNA basic information
circBase ID: -
Name: hsa_circ_FAT1
Synonym: circFAT1(e2) / circFAT1 (e2)
Host Gene: FAT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal brain tissue
Cell lines:

HEB; U87; SW1783; U373; U251; U118
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UN
Associated gene: MYBL2
Associated microRNA: miR-30e-5p
Biological function: promotes glioma cell proliferation, migration and invasion; inhibits apoptosis; promotes cell cycle progression
Molecular mechanism: ceRNA sponge of miR-30e-5p to regulate MYBL2 expression
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes)
Detected method:
Q
B
Validation methods:

divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Northern Blot; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model
Clinical significance:

-
Description:

circFAT1(e2) functions as a cytoplasmic ceRNA that sponges miR-30e-5p, thereby relieving repression of MYBL2. Functionally, circFAT1(e2) supports glioma cell proliferation, cell-cycle progression, migration/invasion, and resistance to apoptosis, and its knockdown suppresses tumor growth in a xenograft model.
Confidence score:

0.7527
Other information
Title:

CircFAT1(e2) acts as a sponge for miR-30e-5p and inhibits glioma progression by regulating MYBL2-mediated cell proliferation.

Journal: Discover oncology
Published: 2025
PubMed ID: 41284124
Study type:

combined biological and clinical study
Data availability: Supplementary material available at 10.1007/s12672-025-03851-y; TCGA (https://portal.gdc.cancer.gov); data available from the corresponding author on reasonable request
Code availability: -