| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-149 |
| Biological function: |
Circ-PVT1 enhances epithelial ovarian cancer cell proliferation and inhibits cell apoptosis. |
| Molecular mechanism: |
Circ-PVT1 directly sponges miR-149 and negatively regulates miR-149 in EOC cells. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
circ-PVT1 may serve as a treatment target in EOC. |
| Description: |
In this study, circ-PVT1 was up-regulated in human epithelial ovarian cancer cell lines compared with normal ovarian surface epithelial cells. Functional assays showed that circ-PVT1 promotes EOC cell proliferation and inhibits apoptosis. Mechanistically, circ-PVT1 directly sponges and negatively regulates miR-149, suggesting a potential therapeutic target role in EOC. |
| Confidence score: |
0.6263 |