| Expression pattern: |
UP |
| Associated gene: |
ELK1, Ago2 |
| Associated microRNA: |
miR-326 |
| Biological function: |
promotes proliferation and invasion; inhibits apoptosis and autophagy; promotes tumor growth in vivo |
| Molecular mechanism: |
acts as a ceRNA/miRNA sponge for miR-326 to upregulate ELK1 |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); autophagy (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Survival Analysis; Transfection; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; FISH / smFISH; In Vivo Animal Model; IHC (Immunohistochemistry); TUNEL; Bioinformatics Analysis |
| Clinical significance: |
Low hsa_circ_0000515 expression was associated with favorable prognosis; patients with low expression had a longer overall survival rate than those with high expression. |
| Description: |
hsa_circ_0000515 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-326 to relieve repression of ELK1, thereby promoting proliferation and invasion while inhibiting apoptosis and autophagy, and its knockdown suppresses xenograft tumor growth. High hsa_circ_0000515 expression is associated with worse overall survival. |
| Confidence score: |
0.8229 |