| Expression pattern: |
UP |
| Associated gene: |
FZD4, Wnt/b-catenin pathway, b-catenin pathway, CCND1, CCND2, MYC, SOX4, TCF7 |
| Associated microRNA: |
miR-516b |
| Biological function: |
promotes CRC cell proliferation, migration, invasion, metastasis and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
circRNA_100290 acts as a ceRNA to sponge miR-516b, upregulates FZD4, and activates Wnt/b-catenin signaling in CRC |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circRNA_100290 expression is positively correlated with tumor metastasis and inversely correlated with prognosis; higher expression predicts worse prognosis |
| Description: |
circRNA_100290 is up-regulated in colorectal cancer tissues and cell lines and its high expression is associated with metastasis and worse prognosis. Functionally, circRNA_100290 promotes CRC cell proliferation, migration, invasion, metastasis and tumor growth while suppressing apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-516b to increase FZD4 expression and activate Wnt/beta-catenin signaling. |
| Confidence score: |
0.7474 |