circRNA basic information
circBase ID: -
Name: hsa_circ_CSPP1
Synonym: circ-CSPP1
Host Gene: CSPP1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; adjacent normal tissues
Cell lines:

NBC; U87; U251; LN229
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes proliferation, migration, invasion, and EMT-like biological behavior of glioma cancer cells
Molecular mechanism: circ-CSPP1 knockdown enhanced E-cadherin expression and decreased N-cadherin and Vimentin expression, indicating regulation of EMT-related protein expression
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Western Blot
Clinical significance:

circ-CSPP1 might serve as a new therapeutic target for the treatment of glioma cancer
Description:

circ-CSPP1 is up-regulated in glioma cancer tissues and cell lines. Functional knockdown experiments in U87 cells indicate that circ-CSPP1 promotes glioma cell proliferation, migration, invasion, and EMT-associated behavior, suggesting potential therapeutic relevance.
Confidence score:

0.5434
Other information
Title:

Roles of circ-CSPP1 on the proliferation and metastasis of glioma cancer.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 32495924
Study type:

combined biological and clinical study
Data availability: -
Code availability: -