| Expression pattern: |
UP |
| Associated gene: |
CYP2S1 |
| Associated microRNA: |
miR-636 |
| Biological function: |
promotes proliferation, migration and invasion and inhibits apoptosis of cervical cancer cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0023404 sponges miR-636 to upregulate CYP2S1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; MTT; EdU Staining; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down Assay; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0023404 is up-regulated in cervical cancer tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. It functions as a ceRNA by sponging miR-636 to derepress CYP2S1, forming the circ_0023404/miR-636/CYP2S1 axis. |
| Confidence score: |
0.7595 |