| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-652 |
| Biological function: |
Promotes malignant progression and cell proliferation of ovarian cancer; circRNA_MYLK knockdown attenuates ovarian cancer cell proliferation. |
| Molecular mechanism: |
circRNA_MYLK binds to and regulates microRNA-652; circRNA_MYLK and microRNA-652 expression are negatively correlated in ovarian cancer tissues. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circRNA_MYLK expression is positively correlated with pathological stage and associated with worse overall survival; it may serve as a biomarker for prognosis detection of ovarian cancer patients. |
| Description: |
circRNA_MYLK is up-regulated in ovarian cancer tissues and cell lines and promotes ovarian cancer cell proliferation. Mechanistically, it binds to and regulates microRNA-652, and its high expression is associated with higher pathological stage and poor prognosis in ovarian cancer patients. |
| Confidence score: |
0.6987 |