| Expression pattern: |
UP |
| Associated gene: |
FGF2 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
Circ_0000615 acts as a positive regulator/oncogene in NPC development; its knockdown suppresses NPC cell proliferation, migration, invasion, EMT, and tumor growth in vivo. |
| Molecular mechanism: |
Circ_0000615 functions as a miR-338-3p sponge and inhibits miR-338-3p expression, thereby upregulating FGF2 and promoting NPC cell progression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; MTT; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Circ_0000615 may be a potential target for the therapy of NPC patients. |
| Description: |
Circ_0000615 is upregulated in NPC tissues and cells and appears to act as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, EMT, and xenograft tumor growth by releasing miR-338-3p-mediated inhibition of FGF2, forming a circ_0000615/miR-338-3p/FGF2 regulatory axis. |
| Confidence score: |
0.7404 |