circRNA basic information
circBase ID: hsa_circ_0000885
Name: -
Synonym: circ_0000885
Host Gene: -
Genomic location(hg19): chr19:7267355-7267907:-
Genomic location(hg38): chr19:7267344-7267896:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

osteosarcoma tissues; corresponding non-tumor tissues; adjacent non-tumor tissues
Cell lines:

SOSP-9607; MG-63; Saos-2; hFOB 1.19
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: Caprin1
Associated microRNA: -
Biological function: enhances osteosarcoma cell proliferation and regulates cell cycle
Molecular mechanism: circ_0000885 promotes osteosarcoma progression by upregulating Caprin1 mRNA and protein expression
Biological pathway or process:

proliferation (promotes); cell cycle (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Western Blot
Clinical significance:

provided a novel therapy target for osteosarcoma
Description:

circ_0000885 is up-regulated in osteosarcoma tissues and cell lines. Knockdown experiments in MG-63 cells indicate that circ_0000885 promotes osteosarcoma cell proliferation and cell-cycle progression, at least partly by upregulating Caprin1 expression. The study suggests circ_0000885 as a potential therapeutic target for osteosarcoma.
Confidence score:

0.5414
Other information
Title:

Caprin1 targeted by circular circ_0000885 in the tumor progression of osteosarcoma.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 32432729
Study type:

combined biological and clinical study
Data availability: -
Code availability: -