circRNA basic information
circBase ID: hsa_circ_0014130
Name: -
Synonym: circ_0014130
Host Gene: -
Genomic location(hg19): chr1:151206672-151212515:+
Genomic location(hg38): chr1:151234196-151240039:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor specimens; paracancerous normal tissues; CRC tissues
Cell lines:

NCM460; HCT116; LoVo; HCT116/5-FU; LoVo/5-FU
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PFKFB3
Associated microRNA: miR-197-3p
Biological function: Promotes CRC cell proliferation, migration, invasion, glycolytic metabolism, tumor growth, and 5-FU resistance; inhibits apoptosis.
Molecular mechanism: circ_0014130 acts as a sponge for miR-197-3p and positively regulates PFKFB3, thereby modulating CRC progression and 5-FU resistance.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); oxidative phosphorylation (inhibits); chemoresistance (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

circ_0014130 is up-regulated in colorectal cancer tissues and cells, especially in 5-FU-resistant samples. It promotes CRC cell proliferation, migration, invasion, glycolytic activity, tumor growth, and 5-FU resistance while suppressing apoptosis. Mechanistically, circ_0014130 sponges miR-197-3p and positively regulates PFKFB3 within the circ_0014130/miR-197-3p/PFKFB3 axis.
Confidence score:

0.705
Other information
Title:

Circ_0014130 is involved in the drug sensitivity of colorectal cancer through miR-197-3p/PFKFB3 axis.

Journal: Journal of gastroenterology and hepatology
Published: 2022
PubMed ID: 35288979
Study type:

combined biological and clinical study
Data availability: -
Code availability: -