circRNA basic information
circBase ID: hsa_circ_0009076
Name: hsa_circ_NRDC
Synonym: circNRDC
Host Gene: NRDC
Genomic location(hg19): chr1:52293467-52299842:-
Genomic location(hg38): chr1:51827795-51834170:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissue; normal gastric mucosa; matched paracancerous tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: SERPINE1
Associated microRNA: hsa-mir-143-3p
Biological function: unknown
Molecular mechanism: Predicted ceRNA mechanism via miRNA sponging (hsa-mir-143-3p) to regulate SERPINE1 in a circRNA-miRNA-mRNA network.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0009076 (circNRDC) is identified as a down-regulated circRNA in gastric cancer tissues by GEO microarray integration. The study predicts a circRNA/miRNA/mRNA axis hsa_circ_0009076-hsa-mir-143-3p-SERPINE1 as part of a putative ceRNA regulatory network, without experimental wet-lab validation.
Confidence score:

0.1768
Other information
Title:

Identification of Potentially Functional CircRNA-miRNA-mRNA Regulatory Network in Gastric Carcinoma using Bioinformatics Analysis.

Journal: Medical science monitor : international medical journal of experimental and clinical research
Published: 2019
PubMed ID: 31747387
Study type:

bioinformatics study
Data availability: GSE78092; GSE89143; GSE93415; GSE54129; TCGA
Code availability: -