| Expression pattern: |
UP |
| Associated gene: |
NOVA2 |
| Associated microRNA: |
miR-330-5p |
| Biological function: |
promotes proliferation, migration, invasion and angiogenesis (tube formation) and inhibits apoptosis in lung adenocarcinoma cells; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_0004140 sponges miR-330-5p to upregulate NOVA2 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); angiogenesis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; EdU Staining; Western Blot; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
circ_0004140 is up-regulated in lung adenocarcinoma tissues/cell lines and functions as an oncogenic circRNA. It sponges miR-330-5p to relieve repression of NOVA2, thereby promoting proliferation, migration, invasion and angiogenesis and inhibiting apoptosis, and it supports tumor growth in a cell line-derived xenograft model. |
| Confidence score: |
0.7418 |