| Expression pattern: |
UP |
| Associated gene: |
CDK4 |
| Associated microRNA: |
miR-5112 |
| Biological function: |
Promotes NSCLC cell proliferation, migration and invasion, and inhibits apoptosis. |
| Molecular mechanism: |
circRNA_001010 acts as a competing endogenous RNA and molecular sponge for miR-5112, relieving miR-5112-mediated inhibition of CDK4 and increasing CDK4 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Wound Healing Assay |
| Clinical significance: |
circRNA_001010 was upregulated in human NSCLC patients and was suggested as a potential target for therapy of NSCLC. |
| Description: |
circRNA_001010 is up-regulated in human NSCLC tissues and A549 cells. It promotes proliferation, migration and invasion and inhibits apoptosis-related gene expression changes in NSCLC cells. Mechanistically, it functions as a ceRNA sponge for miR-5112 to increase CDK4 expression. |
| Confidence score: |
0.6479 |