| Expression pattern: |
UP |
| Associated gene: |
NT5E |
| Associated microRNA: |
miR-330-3p |
| Biological function: |
circ_ASAP2 promotes cisplatin resistance, proliferation, cell cycle progression, colony formation, migration, invasion and tumor growth, and inhibits apoptosis in DDP-resistant gastric cancer cells. |
| Molecular mechanism: |
circ_ASAP2 directly binds miR-330-3p and promotes NT5E expression through a ceRNA-like miR-330-3p/NT5E axis, thereby regulating cisplatin sensitivity and malignant behaviors. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Transfection; MTT; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Clinical Sample Validation; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_ASAP2 was overexpressed in DDP-resistant gastric cancer tissues and may represent a therapeutic target for DDP-resistant gastric cancer. |
| Description: |
circ_ASAP2 is up-regulated in cisplatin-resistant gastric cancer tissues and cells. It promotes DDP resistance and malignant behaviors by binding miR-330-3p and increasing NT5E expression, while circ_ASAP2 knockdown enhances drug sensitivity, induces apoptosis, suppresses proliferation, migration and invasion, and reduces xenograft tumor growth. |
| Confidence score: |
0.7183 |