| Expression pattern: |
DN |
| Associated gene: |
FOXK2 |
| Associated microRNA: |
miR-93-5p |
| Biological function: |
inhibits cell proliferation, migration, invasion, and tumorigenesis; suppresses malignant behaviors of cervical cancer cells |
| Molecular mechanism: |
ceRNA mechanism by sponging miR-93-5p and regulating FOXK2 expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); apoptosis (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; Western Blot |
| Clinical significance: |
circ-ITCH may be a therapeutic target for the management of cervical cancer |
| Description: |
circ-ITCH is down-regulated in cervical cancer and functions as a tumor suppressor. It inhibits proliferation, migration, invasion, and tumor growth by acting as a ceRNA for miR-93-5p and thereby increasing FOXK2 expression. |
| Confidence score: |
0.6261 |