| Expression pattern: |
DN |
| Associated gene: |
Notch1, Ago2, NF-kappaB signaling, p65, p50 |
| Associated microRNA: |
miR-449a |
| Biological function: |
circRNA-000911 acts as an anti-oncogenic circRNA in breast cancer; its overexpression suppresses cell proliferation, colony formation, migration and invasion, and promotes apoptosis. |
| Molecular mechanism: |
circRNA-000911 functions as a miRNA sponge for miR-449a, thereby positively regulating Notch1 expression and suppressing downstream NF-kappaB signaling. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); NF-kappaB (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; circRIP; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circRNA-000911 may serve as a prognostic biomarker and promising therapeutic target for patients with breast cancer. |
| Description: |
circRNA-000911 is downregulated in breast cancer tissues and cells. It acts as a tumor suppressor by sponging miR-449a, increasing Notch1 expression, suppressing NF-kappaB signaling, and inhibiting proliferation, migration and invasion while promoting apoptosis. |
| Confidence score: |
0.7981 |