| Expression pattern: |
UP |
| Associated gene: |
FN1 |
| Associated microRNA: |
miR-384 |
| Biological function: |
circCNOT6L promotes ESCC cell proliferation, iron metabolism disorder and tumor growth, and inhibits apoptosis. |
| Molecular mechanism: |
circCNOT6L acts as a competing endogenous RNA for miR-384 to modulate FN1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
provided a theoretical basis and a potential target for the therapy of ESCC patients |
| Description: |
circCNOT6L is up-regulated in ESCC tissues and cells and functions as an oncogenic circRNA. It promotes ESCC cell proliferation, iron metabolism disorder and tumor growth while suppressing apoptosis, at least partly by sponging miR-384 to increase FN1 expression. |
| Confidence score: |
0.7785 |