circRNA basic information
circBase ID: hsa_circ_0000847
Name: hsa_circ_SMAD2
Synonym: circSMAD2
Host Gene: SMAD2
Genomic location(hg19): chr18:45391429-45423180:-
Genomic location(hg38): chr18:47865058-47896809:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-tumorous liver tissues
Cell lines:

Huh7; HepG2; SMMC-7721; BEL-7402; HL7702
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Upregulated in HCC tissues and associated with TNM stage; no functional assays were reported for circSMAD2 in this study.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation
Clinical significance:

circSMAD2 expression was related to TNM stage.
Description:

circSMAD2 was selected from RNA-seq data as an upregulated circRNA and was validated by qRT-PCR as significantly higher in HCC tissues than paired adjacent non-tumorous liver tissues. Its expression was associated with TNM stage, but the study did not perform circSMAD2-specific functional or mechanistic assays.
Confidence score:

0.3588
Other information
Title:

Circular RNA expression and circPTPRM promotes proliferation and migration in hepatocellular carcinoma.

Journal: Medical oncology (Northwood, London, England)
Published: 2019
PubMed ID: 31494761
Study type:

combined biological and clinical study
Data availability: GSE125469
Code availability: -